Scientist - Gene Delivery and Editing Process Development

Working with Us
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Title: Scientist - Gene Delivery and Editing Process Development

Location: Seattle, WA

We are looking for a successful scientist who will directly employ techniques for the in vitro production of oligonucleotides, and biophysical and analytical tools to develop our next-generation gene edited therapies. An outstanding candidate will be driven by a desire to create, optimize, and define novel processes that are not currently utilized by BMS.

Key Responsibilities:

1. Execute nucleic acid ligation reactions using “splint ligation” methodology.
2. Execute in vitro transcription reactions to produce RNA.
3. Execute downstream purification of crude RNA products using anion exchange chromatography, reverse-phase (RP) chromatography, and buffer exchange unit operations.
4. Execute ion-pairing RP chromatography assays to measure RNA full-length product purity.
5. Execute native and denaturing PAGE (or capillary electrophoresis, CE) assays.
6. Execute Cas nuclease binding assays (fluorescence based) for various gRNA constructs.
7. Actively participate and support lab maintenance and continuous improvement initiatives.
8. Maintain accurate and detailed laboratory notebooks and documentation.
9. Summarize and present data in group meetings and contribute to group discussions.
10. Author technical memos and reports.

Qualifications & Experience:

1. STEM degree with 2+ years of relevant industry experience.
2. Experience working with, storing, and analyzing purified nucleic acids and proteins.
3. Independently motivated, and possesses the ability to work creatively with limited resources.
4. Ability to communicate clearly and concisely through oral presentation and technical writing.
5. Ability to leverage literature, and internal and external resources to form hypotheses.
6. Degree in chemistry, biochemistry, molecular biology, or bio-related field, preferred.
7. Experience with optimizing molecular cloning reactions, preferred.
8. Familiarity with bioinformatic tools used to predict RNA secondary structure, preferred.
9. Experience with JMP for DoE design and analysis, preferred.

The starting compensation for this job is a range from $97,000 - $121,000, plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.

Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.